Abstract
Body weights of Snell (dw/dw) and Ames (df/df) dwarf mice doubled after intracranial implantation of hollow fiber units containing mouse pituitary cells. Recipients showed increased long bone growth, increased fat deposition, and marked loss of body hair. Recipients injected with thyroxine grew but did not develop increased fat deposition or hair loss. The results suggest that both somatotrophs and corticotrophs function in the fiber implants.
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