Abstract
The action of each of the purified pituitary hormones has been assessed in maintenance and repair of the reproductive system of the hypophysectomized 40-day male rat. When injections of interstitial cell stimulating hormone (ICSH) were begun immediately after hypophysectomy, the testicular weight and physiological status of tubules and Leydig cells were maintained and advanced. Testicular epithelium was extremely sensitive to low doses of ICSH and sperm were elaborated. Even at high doses of ICSH, testicular and accessory organ weights were not, however, completely normal for the chronological age. Follicle stimulating hormone (FSH), injected at doses which did not show contamination with ICSH, had only slight effects on testicular weight and development; only the highest levels of FSH injected caused barely perceptible stimulation of the accessory organs. However, low doses of FSH injected with ICSH increased testicular size and development. Doses of lactogenic and growth hormones, having no effect on th...
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