Pituitary content of oxytocin, vasopressin and alpha-melanocyte-stimulating hormone in the fetus of the rat during labour.

Abstract

The pituitary contents of oxytocin, vasopressin and alpha-MSH were measured in fetal and newborn rats to assess possible changes in their release during the process of labour. In the 24 h period during which delivery is likely to occur in the Wistar rat, both the oxytocin and vasopressin content of the fetal pituitary gland increased, whereas alpha-MSH content remained the same. During and/or just before labour, the oxytocin content was found to decrease by 30%, indicating an enhanced fetal release of the hormone at this stage. It was concluded that the expulsion of each fetus did not provide an extra stimulus for release of oxytocin by the fetus. In addition, if the fetus remained in the uterus after decapitation of the mother, the oxytocin content of the fetal pituitary gland decreased a further 30%. Neither vasopressin nor alpha-MSH content was altered by the process of labour or by the fetus remaining in the uterus after decapitation of the mother. The levels of vasopressin and alpha-MSH were, however, 20 times higher than the oxytocin content in the fetus and the newborn, which might have obscured the demonstration of a relatively small change in levels of these two hormones.