Abstract
A LYMPHOPENIA and profound alterations in lymphoid tissue were among the earliest described physiological effects of Roentgen radiation. Indeed, the lymphocyte has been shown by many investigators to be the most radiosensitive of body cells (Dunlap, 1942). The extensive literature describing the effects of radiation on lymphoid tissue has been summarized by Murphy (1926) and, more recently, by Selling and Osgood (1938). The similarities between the described changes produced in lymphoid tissue by Roentgen radiation and those seen following a single injection of either pituitary adrenotrophic hormone or adrenal cortical preparations (Dougherty and White, 1945) suggested that pituitary-adrenal cortical secretion might be a normal, physiological mechanism concerned with certain of the physiological actions of X-rays.
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