Abstract
Chlorhexidine (CHX) is a synthetic biguanide available in different forms (diacetate, dihydrochloride, and digluconate) and used as an antiseptic. In the past few years, there has been a substantial increase in the number of CHX-containing products used in health care. Hypersensitivity reactions to CHX are increasingly reported and include allergic contact dermatitis, photosensitivity, fixed drug eruptions, asthma, and lifethreatening anaphylaxis. Here, we report 3 cases of anaphylaxis due to CHX with a particular course, highlighting possible pitfalls and peculiarities in CHX allergy.
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