Abstract
Muscarinic stimulation of mucus secretion, as measured by the release of [ 3H]glycoprotein, was studied in explants from the tracheal epithelium of weanling swine. The mucus glycoprotein secretion was transient, ceasing within the first 10 min of a continuous exposure to 100 μM ACh. Increasing the solution's osmotic pressure did not alter basal mucus glycoprotein secretion. Mucus glycoprotein secretion was inhibited by 2–10 μM PZP, indicating that the M 3 muscarinic receptors mediate cholinergic stimulation of mucus production.
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