Abstract
Insulin is secreted from pancreatic β cells in response to glucose metabolism altering intracellular ATP:ADP ratios and promoting calcium influx. Secretion is biphasic with a strong first phase and a sustained second phase. This probably relates to the dynamics of the pools of insulin-containing granules. How this might be regulated by physiological ATP:ADP ratios impinging on phosphatidylinositol kinases and phosphatidylinositol phosphates (PIPs) has recently been addressed. The results suggest an additional layer of control of stimulus – secretion coupling by ATP:ADP – and provide an exciting model for basic research and also new putative targets for therapy.
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