Abstract
Aggression in isolated male mice and hypermotility in rats produced by the noradrenaline releaser H 77/77 were studied after the s.c administration of the α-adrenergic agonist clonidine and the α-antagonist piperoxane. Clonidine 0.005–0.5 mg/kg inhibited both behaviours while piperoxane showed a weak and short-lasting anti-aggressive aggressive effect and no 77/77 antagonism. Inactive doses of piperoxane reduced the inhibitory effects of clonidine. The results indicate that isolation-induced aggression in mice and H 77/77-induced hypermotility in rats are behavioural signs related to the availability of noradrenaline at the receptor.
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