Abstract
Objective To observe the clinical effects of pioglitazone and telmisartan on the stage Ⅲ～Ⅳ of diabetic nephropathy.Methods In this study,63 cases of diabetic nephropathy were random-ly divided into 3 groups : pioglitazone group ( n = 19), telmisartan group ( n = 22) and combination group( n = 22).The median follow-up duration was 3 months.Levels of FBG,2 hBG, HbA1 c ,24 h u-rinary protein and SCr were compared before and after treatment.Results 24h urinary protein were de-creased in three groups after treatment ( P＜0.05 ), but descent of 24h urinary protein in combination group was better than the others ( P＜0.01 ).Conclusions Pioglitazone and telmisartan can both re-duce the excretion rate of urinary protein, and the combination use is better than the single use of them. Key words: Telmisartan; Pioglitazone; Diabetic nephropathy
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