Abstract
Ping-Pong Positioning: Alternating Protein Interactions at Actin Filament Barbed Ends Helps Establish Polarity in Mammalian Oocytes
Highlights
For mammalian egg cells to form successfully, the precursor cell must divide asymmetrically, forming a large egg that contains the storage material required for embryo development, and a small polar body that receives surplus chromosomes
Exactly how do these three proteins work together to accomplish this important task? A new in vitro study by Marie-France Carlier, Pierre Montaville, and colleagues has revealed a fascinating ping-pong like interaction between Formin 2 and Spire acting on profilin-bound actin
It was known that the C-terminus of the FH2 domain of Formin 2 associates with the N-terminal (Nt) KIND domain of Spire
Summary
For mammalian egg cells to form successfully, the precursor cell (the oocyte) must divide asymmetrically, forming a large egg that contains the storage material required for embryo development, and a small polar body that receives surplus chromosomes. Ping-Pong Positioning: Alternating Protein Interactions at Actin Filament Barbed Ends Helps Establish Polarity in Mammalian Oocytes The meshwork-building process involves three actin-binding proteins named profilin, Formin 2, and Spire ( known to display genetic interactions in Drosophila), which cooperate in vivo.
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