PIN80 - A Multicenter, Observational Study To Evaluate Comorbidities In Patients Above 50 Years of Age – Aging Positive: A Comparison of Medical Charts And Patients Self-Reported Data

Abstract

The primary objective of AGING POSITIVE is to characterize non-AIDS-related comorbidities of interest among HIV-infected patients ≥ 50 years old. This poster focuses the results of an exploratory objective: to compare patient self-reported data on comorbidities, current co-medication and healthcare resource use with the equivalent data collected from the medical charts. Multicenter, cross-sectional study conducted in seven Portuguese centers specialized in the treatment of HIV/AIDS. Data was collected from hospital medical records and through a patient self-administered questionnaire. Concordance between data obtained by investigator through medical records and the patient-reported knowledge was analyzed using Kappa concordance coefficient for qualitative variables and intraclass correlation coefficient for quantitative variables. A total of 401 patients were recruited between Nov/15 and Jun/16. Patient’s mean age was 59.3 years (SD) and the mean infection duration was 12 years (SD 6.17). All patients filled the questionnaire. The most frequent comorbidities were the same for data collected from medical charts and self-reported data – hypercholesterolemia, hypertension and depression/chronic anxiety. The comparative analysis showed a statistical significant concordance between non-AIDS comorbidities of interest collected from self-administered questionnaire and equivalent data collected from medical charts. For all comorbidities, the rate of concordant answers was greater than 93% (except for hypercholesterolemia: 87.8%) and the Kappa concordance coefficient show a good and very good agreement. The comparative analysis of co-medication also depicted a general good and very good concordance (except for hepatitis C which showed a moderate concordance), with a statistical significant Kappa concordance coefficients and a higher rate of concordant answers. Lipid lowering agents, antihypertensives and antidepressants/anxyolitics were the most frequent co-medications. Results of healthcare resources showed a moderate and good correlation in comparison of self-reported versus medical charts data. Data in medical charts and patient-reported knowledge is highly concordant both in terms of comorbidities as co-medication.