Abstract
Around 2 million people die every year from pneumococcal infections world-wide. 50% of them are children. In Austria around 9,000 children (<5 years) develop pneumococcal infections every year. About 20 children develop invasive pneumococcal disease (IPD). Vaccination with a pneumococcal conjugate vaccine (PCV) for all children <2 years is recommended and reimbursed in Austria. Currently PCV10 is being used exclusively but could now be replaced by PCV13. The aim of this BIA is to quantify the monetary impact of an increasing proportion of PCV13 vaccinated children in the different age-groups compared to the present situation, after an observed serotype shift of reported cases. A multi-cohort, population-based model was developed over a 5-year time-horizon, which included the following states: hospitalized and outpatient pneumococcal-disease (pneumonia, meningitis and AOM), IPD, associated complications and mortality in children <5. Within the present vaccination coverage of 80%; 75% receive PCV10; 15% PCV13. The model evaluates PCV10 being replaced by PCV13 with PCV13 achieving 83% market share in year 5. The model includes a serotype shift over time. Results included savings that could be achieved from the health-care-systems perspective. Based on the current vaccination coverage annual savings of 1.1 million € (m€) (1st year) to 3 m€ (5th year) [total: 10.6 m€ over 5 years] could be achieved. A market shift will reduce pneumococcal disease from 1,013 (1st year) to 2,821 (5th year) [total: 9,100 cases over 5 years]. Between 4 (1st year) and 11 (5th year) cases of IPD per year could be prevented [total: 36 over 5 years]. Prevented deaths range from 2 (1st year) to 6 (5th year) per year [total: 19 over 5 years]. An increase in PCV13 vaccinated children – due to a change in the national immunization program – could reduce overall disease-burden substantially and lead to considerable savings.
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