Pilot Therapeutic Protocol for the Treatment of Local Advanced Disease, such as the Generalized Peritoneal Carcinomatosis and for the Treatment of Distant Metastases in Human Malignant Neoplastic Disease – Targeting the Medium

Abstract

The phenomenon of life and the open thermodynamic systems in general may be described from the existence of (i) a distinct separating border from the surrounding environment (ii) specific structures inside it, which are functioning with some form of energy exchange with the environment and (iii) the medium inside wherewith these functions are taking place. For living cells, this distinct border is the cell membrane, the structures are the cellular organelles and the medium is the cytoplasm (which is mainly consists of water). The research idea of this therapeutic protocol aims at the selective destruction of the “medium”, namely the cytoplasm of the cancer cell, with concurrently preservation of the integrity of the cytoplasm of the nearby normal cells/tissues. This may be achieved with the gradual lowering of the core body temperature of the patient and concurrently introducing of a therapeutic solution of complementary, “anti-sense”, polypeptides in the cancer cell, individually synthesized for every patient, accordingly to his malignancy type, with theoretically increasing of the freezing point of the malignant cell’s cytoplasm, subsequent crystallization, expansion and rupture of its membrane at a temperature where the cytoplasm of the nearby healthy cells/tissues will remain intact.