Abstract
Disfunction of immune system and neuroinflammation may play a role in pathogenesis of schizophrenia. The role of adaptive immune system has to be elucidated. We present a pilot study to test the methodology of profiling of immune repertoires of the TCR gamma chain by deep sequencing using several patients with juvenile schizophrenia and unaffected control subjects. The clonotype profiles were revealed and their diversity and presumable differences in structure of CDR3 TRG region of functional clones in juvenile schizophrenia and controls were estimated. This approach is perspective for further comprehensive study of changes in adaptive immune system in representative cohorts of patients with different forms of schizophrenia.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
