Abstract
Meeting abstracts Cryo is an effective modality for pain palliation and local control of soft tissue and bone metastases. Cryo induces necrotic cell death, and combination cryo with anti-CTLA-4 generates potent systemic anti-tumor immune responses in preclinical models and small clinical studies.
Highlights
Cryo is an effective modality for pain palliation and local control of soft tissue and bone metastases
We report the safety and efficacy of IT cryo and systemic ipilimumab or pembrolizumab in patients with MM
Exploratory immune correlates from peripheral blood and tumor samples were obtained when available
Summary
Pilot study of intratumoral (IT) cryoablation (cryo) in combination with systemic checkpoint blockade in patients with metastatic melanoma (MM). Dae Won Kim1*, Cara Haymaker, Natalie McQuail, Elizabeth Sirmans, Christine Spencer, Isabella Glitza, Rodabe Amaria, Scott Woodman, Sapna Patel, Michael Davies, Cassian Yee, Wen-Jen Hwu, Chantale Bernatchez, Jennifer Wargo, Padmanee Sharma, James Allison, Patrick Hwu, Alda Tam, Adi Diab. From 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015) National Harbor, MD, USA. From 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015) National Harbor, MD, USA. 4-8 November 2015
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