Abstract
Despite advances in the development of pharmacotherapy for alcohol use disorder (AUD), there remains a need for medications that can be administered to actively drinking outpatients to promote a reduction in harmful alcohol consumption. The primary aim of this pilot study was to determine whether high-dose gabapentin (3600mg/daily) is more effective than placebo in reducing harmful alcohol consumption in outpatients with AUD. Forty patients (27 men) who met DSM-IV-TR criteria for alcohol dependence and reporting at least 4heavy drinking days (HDD) per week were recruited at a single site. Participants were actively drinking at study entry and received double-blind gabapentin (3600mg/day; n=19) or placebo (n=20) for 8weeks. Study medication was titrated over 5days and administered in three divided doses (1200mg three times per day). The proportion of HDD (primary outcome) and percent days abstinent (PDA; secondary outcome) were analyzed using generalized longitudinal mixed models with the predictors being study arm, week, study arm by week interaction, and corresponding baseline drinking measure. There was a significant interaction between study arm and week for the proportion of HDD per week, F (7, 215)=3.33, p=0.002 . There was also a significant interaction between study arm and week for PDA per week, F (7, 215)=3.11, p=0.004. The overall retention rate was 67.5% with no significant difference in time-to-dropout between treatment groups. There were no serious adverse events. No participants were removed from the trial due to the development of moderate-to-severe alcohol withdrawal (CIWA-Ar≥13). Gabapentin treatment rapidly titrated to a dosage of 3600mg/day is associated with a reduction in the proportion of HDD per week and an increase in PDA per week in actively drinking outpatients with AUD. High-dose gabapentin is potentially a feasible approach to treating AUD and deserving of further study.
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