Pigs and Ferrets as Models in Toxicology and Biological Safety Assessment

Abstract

Both the pig and the ferret are used as animal models in toxicology and drug development, with the pig having been subject to a significant increase in usage (particularly in Europe) over the last 5 years. These two species are quite different from primates and dogs, the “standard” nonrodent models. This article seeks to both survey the rationales for and extent of use of the pig and ferret, and to highlight consideration and key factors in their use in studies.