Abstract
ABSTRACTObjective: To determine the progression of pigment dispersion syndrome (PDS) into pigmentary glaucoma (PG) in a population at the Central Military Hospital in Bogotá, Colombia.Materials and methods: A retrospective study was conducted, based on a review of medical records of patients with PDS evaluated in the Glaucoma Clinic. Data were collected in a database in excel and subsequently analyzed with the software Statistical Package for the Social Sciences (SPSS), performing Chi-square test analysis and Spearman’s rho test.Results: Forty-eight eyes of 24 patients were included. Forty-two percent were women and 58% were men. Pigmentation of the trabecular meshwork was the most frequent clinical sign (100%), followed by Krukenberg’s spindle (91.7%), the least frequent were the iris concavity and iris heterochromia (4.2%), the average of the spherical equivalent was of - 1.33 (SD 2.07).The rate of conversion of PDS to PG was 37.5%, after an average follow-up of 50.7 months. Having an intraocular pressure (IOP) greater than 21 mm Hg was statistically the only significant risk factor for conversion.Conclusion: We found several differences in frequency and clinical signs in these patients in contrast to previous data, probably due to different racial characteristics.The rate of progression is similar to previous reports despite of heterogeneity of these. Having IOP > 21 mm Hg was the only risk factor associated with progression in this sample.How to cite this article: Gomez Goyeneche HF, Hernandez-Mendieta DP, Rodriguez DA, Sepulveda AI, Toledo JD. Pigment Dispersion Syndrome Progression to Pigmentary Glaucoma in a Latin American Population. J Curr Glaucoma Pract 2015;9(3):69-72.
Highlights
The pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) are two consecutive and progressive stages of an uncommon pathological process, characterized by a release and subsequent deposit, especially in anterior chamber and trabecular meshwork[1,2] of pigment granules originated in the posterior pigment epithelium of iris, these situation may result in increased intraocular pressure (IOP) and optic nerve damage.[3,4]The exact triggers for this condition are not fully understood, there are many factors involved including genetic,[5] immune-mediated damage,[6] among others
The rate of progression is similar to previous reports despite of heterogeneity of these
Having IOP > 21 mm Hg was the only risk factor associated with progression in this sample
Summary
The pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) are two consecutive and progressive stages of an uncommon pathological process, characterized by a release and subsequent deposit, especially in anterior chamber and trabecular meshwork[1,2] of pigment granules originated in the posterior pigment epithelium of iris, these situation may result in increased intraocular pressure (IOP) and optic nerve damage.[3,4]The exact triggers for this condition are not fully understood, there are many factors involved including genetic,[5] immune-mediated damage,[6] among others. The pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) are two consecutive and progressive stages of an uncommon pathological process, characterized by a release and subsequent deposit, especially in anterior chamber and trabecular meshwork[1,2] of pigment granules originated in the posterior pigment epithelium of iris, these situation may result in increased intraocular pressure (IOP) and optic nerve damage.[3,4]. Pigment dispersion syndrome and PG are not common for Latin American population, and there is no previous information in databases about the behavior and evolution of these conditions. To our knowledge, this is the first study of this group describing the rate of progression from pigmentary dispersion syndrome to PG
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