Abstract
Recent studies of the ultrastructure and enzyme activity of nevus cells have refocused attention on the relationship between the nevus cell and the epidermal melanocyte and have allowed further speculation about the origin of the dermal nevus. Mishima and Schaub (1) and Gottlieb and associates (2) have demonstrated with the electron microscope characteristic organelles within the cytoplasm of dermal nevus cells that resemble the melanosome of the epidermal melanocyte. Mishima and Schaub also have reported that tyrosinase activity may be induced within dermal nevus cells by ultraviolet light irradiation (1). We shall present further enzyme histochemical studies of light-irradiated dermal nevi, involving both tyrosinase and nonspecific cholinesterase activity.
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