Abstract
In-vitro percutaneous absorption of hydrophilic (water and mannitol) and moderately lipophilic (benzyl alcohol) solutes was investigated through pig ear epidermis and compared with the permeability of these solutes reported for human epidermis. Factors of difference in permeabilities of pig epidermis in comparison with human epidermis were 2.74, 1.2, and 0.58 for water, mannitol, and benzyl alcohol, respectively. An animal model may be predictive of human skin permeability if the factor of difference value between the species is less than 3. This suggests that pig ear skin can be used as a model for man for predicting percutaneous absorption of hydrophilic and moderately lipophilic solutes.
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