Abstract
The title compound, 2-p-tolyl-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole, C16H16N2S, is a condensation product of pifithrin-α, which has been previously reported as an inhibitor of the tumour suppressor protein p53. The molecule contains a planar fused pair of heterocyclic five-membered rings and the attached p-tolyl substituent is also essentially coplanar.
Highlights
The title compound, 2-p-tolyl-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole, C16H16N2S, is a condensation product of pifithrin, which has been previously reported as an inhibitor of the tumour suppressor protein p53
The compound was prepared by a condensation reaction of pifithrin, initially unintentionally during a study of anti-tumour agents, and subsequently by refluxing in aqueous methanol (Walton et al, 2005)
Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2)
Summary
The title compound, 2-p-tolyl-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole, C16H16N2S, is a condensation product of pifithrin-, which has been previously reported as an inhibitor of the tumour suppressor protein p53. Single planar unit [r.m.s. deviation 0.009 A ; dihedral angle between the two five-membered rings = 1.32 (5)] Such imidazo[2,1-b]thiazole fused ring systems have been found in ten other crystal structures in the Cambridge Structural Database (Version 5.26 plus one update, February 2005; Allen, 2002), and they are all planar. The compound was prepared by a condensation reaction of pifithrin, initially unintentionally during a study of anti-tumour agents, and subsequently by refluxing in aqueous methanol (Walton et al, 2005).
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