Abstract
Thin films of analyte-specific hydrogels were combined with microfabricated piezoresistive pressure transducers to obtain chemomechanical sensors that can serve as selective biochemical sensors for a continuous monitoring of metabolites. The gel swelling pressure has been monitored in simulated physiological solutions by means of the output signal of piezoresistive sensors. The interference by fructose, human serum albumin, pH, and ionic concentration on glucose sensing was studied. With the help of a database containing the calibration curves of the hydrogel-based sensors at different values of pH and ionic strength, the corrected values of pH and glucose concentration were determined using a novel calibration algorithm.
Highlights
Hydrogels are three-dimensionally cross-linked hydrophilic polymer networks swollen in water which are able to undergo a volume phase transition under the influence of environmental changes.The amount of solvent uptake depends on the polymer structure and composition, and can be madeChemosensors 2014, 2 responsive to environmental factors, such as temperature, pH-value, ion concentration, salt concentration, analyte molecule concentration in solutions, and solvent composition.The ability to customize the hydrogels’ chemical and mechanical characteristics allows for the synthesis of hydrogels optimized for detection of particular target species in a physiological concentration range
We examined the dependence of glucose sensing upon interferences by fructose and human serum albumin at physiological pH and physiological levels of interfering molecules
The output characteristics of the sensors were measured taking into account the investigated cross-sensitivities of polyelectrolyte hydrogels
Summary
Hydrogels are three-dimensionally cross-linked hydrophilic polymer networks swollen in water which are able to undergo a volume phase transition under the influence of environmental changes.The amount of solvent uptake depends on the polymer structure and composition, and can be madeChemosensors 2014, 2 responsive to environmental factors, such as temperature, pH-value, ion concentration, salt concentration, analyte molecule concentration in solutions, and solvent composition.The ability to customize the hydrogels’ chemical and mechanical characteristics allows for the synthesis of hydrogels optimized for detection of particular target species in a physiological concentration range. Chemosensors 2014, 2 responsive to environmental factors, such as temperature, pH-value, ion concentration, salt concentration, analyte molecule concentration in solutions, and solvent composition. The diagnosis and management of metabolic diseases, such as diabetes mellitus, requires a simultaneous and continuous monitoring of several metabolites (blood glucose level, pH-value, concentration of CO2) throughout day with the help of measuring systems. In this regard, a new challenge is an implantable sensor array microsystem consisting of several hydrogel-based sensors that can provide a continuous monitoring and on-line control of physiological parameters in the body fluid
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