Abstract
The in vitro selection of sperm for intracytoplasmic sperm injection (ICSI) is critical and directly influences the paternal contribution to preimplantation embryogenesis. Hyaluronan (H), a major constituent of the cumulus matrix, may play a critical role in the selection of functionally competent sperm during in vivo fertilization. H-bound (HB) sperm carry increased levels of developmental maturity and sperm chromatin integrity. The relationship between HB-sperm and potentially enhanced levels of functional competence led to the current study examining the use of HB-sperm in the treatment of ICSI patients.
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