Abstract
Two picrotoxane sesquiterpene lactone glycosides, nepalactones A (1) and B (2), and one new coumarin, nepalarin (3), were isolated from the root barks of the poisonous plant Coriaria nepalensis. Their structures were elucidated via HRESIMS and 1D and 2D NMR spectroscopic analyses, and further verified via transformation methods. In addition, compounds 1–3 and five semisynthetic congeners (1a–e) were assayed for the activity to induce neurite outgrowth in rat pheochromocytoma (PC12) cells. As a result, nepalactone A derivative 1c and nepalarin (3) significantly enhanced nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells.
Highlights
Coriaria nepalensis Wall (Coriaria sinica Maxim) (Coriariaceae) is a Chinese medicine herb mainly distributed in the southwest of China
A series of sesquiterpenes [6,7,8,9] and prenyled coumarins [10,11] have been previously identified from C. nepalensis
In our recent effort to search for neurotrophic natural products [13,14,15,16], we employed rat dopaminergic PC12 cells as an in vitro cell model to screen various natural compounds for the effect on nerve growth factor (NGF)-induced neurite outgrowth
Summary
Coriaria nepalensis Wall (Coriaria sinica Maxim) (Coriariaceae) is a Chinese medicine herb mainly distributed in the southwest of China. A series of sesquiterpenes [6,7,8,9] and prenyled coumarins [10,11] have been previously identified from C. nepalensis. Among these sesquiterpene lactones, coriamytin and tutin have been suggested as main bioactive substances for the treatment of schizophrenia [8,12], and as insecticidal agents [9].
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