Abstract
A procedure of extraction purification of picric acid from impurities of dinitrophenols with diethyl ether at pH = 3 has been developed. Purified picric acid was used to determine the creatinine by the Jaffe reaction on model systems and the extraction-photometric determination of the basic substance in higher quaternary ammonium (QAS) and amine impurities in them. It was shown that both the purity and the concentration of picric acid affect the sensitivity of the creatinine quantification. It was found that to determine creatinine, a solution of HPic with a concentration of 0,035 mol/l should be used. The determination of amines in the QAS and basic substance is also necessary to be carried out only with purified picric acid to avoid distortion of the results.
Highlights
A procedure of extraction purification of picric acid from impurities of dinitrophenols with diethyl ether at pH = 3 has been developed
Purified picric acid was used to determine the creatinine by the Jaffe reaction on model systems and the extraction-photometric determination of the basic substance in higher quaternary ammonium (QAS) and amine impurities in them
It was shown that both the purity and the concentration of picric acid affect the sensitivity of the creatinine quantification
Summary
Также пикриновая кислота (точнее, ее соль – пикрат натрия) находит применение для определения аминов ЧАС [5, 6]. Что качество HPic играет важную роль при определении креатинина, особенно примесей аминов в ЧАС и основного вещества. Очищенную HPic применяли для определения креатинина в модельных растворах и содержания основного вещества в ЧАС, а также примесей аминного характера в них.
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