Abstract
In anaphase, entangled DNA between segregating sister chromatids can give rise to DNA threads known as ultrafine anaphase bridges (UFBs). To prevent genome instabilities, UFBs are resolved by a complex protein pathway. It has been proposed that a key step in UFB resolution is the remodeling of nucleosomes by the SNF2 protein PICH. However, direct evidence of nucleosome remodeling by PICH remains elusive. Here, we present a single-molecule assay that recapitulates chromatin re-organization during UFB resolution.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
