Abstract
CEREBROSPINAL fluid (CSF) is formed in the choroid plexuses, in the ventricular cavities through ependymal walls1 and in the subarachnoid space2,3. Some authors3,4, consider that subarachnoid fluid production constitutes 40% or more of the total secreted CSF. The formation of this subarachnoid fluid can be attributed to the pial vessels or be considered as a collection of extracellular fluid produced by the parenchymal capillaries, passing to the subarachnoid space through the pial membrane. Endothelial cells of the respective vessels should possess specific transport properties if they produce a fluid which might be of similar composition to that formed by the plexus. Absorption of the fluid and selective transfer of substances from CSF to blood should also be accomplished. The aim of this investigation was to explore which of the two, pial vessels or parenchymal capillaries, was the preferential route.
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