Abstract
Global transcriptional profiling of human fibroblasts from two different tissue sources reveals distinct as well as conserved responses to different growth stimuli.
Highlights
Serum treatment of quiescent human dermal fibroblasts induces proliferation, coupled with a complex physiological response that is indicative of their normal role in woundhealing
The global transcriptional program of quiescent human dermal fibroblasts stimulated to proliferate by serum treatment indicates that there is a complex physiological wound-healing response that is superimposed upon the expected proliferative response [5]
The genes affected during the proliferative response of cultured fibroblasts to serum are predictive of tumor prognosis and metastasis in different cancers [7], implying that a conserved core set of regulatory mechanisms underlies the transition to proliferation in diverse cell types
Summary
Serum treatment of quiescent human dermal fibroblasts induces proliferation, coupled with a complex physiological response that is indicative of their normal role in woundhealing. The transition of mammalian cells from quiescence to proliferation and their re-entry into the cell cycle (the G0 to G1 transition) underlies diverse normal physiological processes, such as tissue regeneration, wound healing and lymphocyte activation, and it is one of the hallmarks of cancer [1,2,3]. This transition is marked by activation of cell-surface receptors, intracellular signal transduction pathways and effector transcription factors, which in turn lead to altered programs of gene expression, driving cells into the proliferative state. Gene expression analysis of cultured human fibroblasts from skin, lymph node, synovium and tonsil revealed heterogeneity in their expression profiles [8]
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