PI-03 LATE-BREAKING ABSTRACT: PREOPERATIVE SERUM PROSTATE SPECIFIC ANTIGEN LEVELS VARY ACCORDING TO TOPOGRAPHICAL DISTRIBUTION OF PROSTATE CANCER IN PROSTATECTOMY SPECIMENS

Abstract

You have accessJournal of UrologyPlenary Session I: Best Abstract and Late Breaking Abstracts1 Apr 2014PI-03 LATE-BREAKING ABSTRACT: PREOPERATIVE SERUM PROSTATE SPECIFIC ANTIGEN LEVELS VARY ACCORDING TO TOPOGRAPHICAL DISTRIBUTION OF PROSTATE CANCER IN PROSTATECTOMY SPECIMENS Okyaz Eminaga, Reemt Hinkelammert, Elke Eltze, Olaf Bettendorf, and Axel Semjonow Okyaz EminagaOkyaz Eminaga More articles by this author , Reemt HinkelammertReemt Hinkelammert More articles by this author , Elke EltzeElke Eltze More articles by this author , Olaf BettendorfOlaf Bettendorf More articles by this author , and Axel SemjonowAxel Semjonow More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2575AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES It remains unclear whether the spatial distribution of prostate cancer (PCa) influences the concentration of prostate specific antigen (PSA). We conducted the current study that investigated the association between PSA levels and the spatial distribution of PCa. METHODS An observational prospective study was performed in 775 consecutive men with preoperative PSA levels ≤20 ng/ml who underwent radical prostatectomy (RP) for organ-confined PCa. We evaluated prostate specimens using a cMDX-based map model of the prostate and determined the prostate volume (PVol), number of cancer foci, relative tumour volume (%TuVol), Gleason score (GS), zone of origin, localisation, and pathologic stage after stratification according to PSA levels categorised into three groups: <4 ng/ml, 4–10 ng/ml, and 10.1–20 ng/ml. The distribution of 5,254 PCa foci was analysed after stratification according to PSA levels and visualised on heat maps. The colour gradient of the heat maps was reduced to 6 colours representing the frequency classification of PCa using an image posterisation effect. A logistic regression analysis was performed to assess the odds ratios of PSA levels for the presence of PCa in 16 regions. RESULTS PCa with PSA <4 ng/ml was predominantly localised to the apical part and the peripheral zone of the prostate. PCa with a PSA level 10.1-20 ng/ml was observed more frequently in the anterior part and the base of the prostate than PCa with a PSA level ≤10 ng/ml. CONCLUSIONS Preoperative PSA levels vary according to the spatial distribution of PCa in RP specimens. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e222-e223 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Okyaz Eminaga More articles by this author Reemt Hinkelammert More articles by this author Elke Eltze More articles by this author Olaf Bettendorf More articles by this author Axel Semjonow More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...