Abstract
• New β -resorcylic acid derivatives were isolated from an endophyte L . theobromae . • Absolute configuration was established using Mosher's ester analysis and chemical ECD calculations. • (3 S, 7 R )-17- O -methyl- de - O -methyllasiodiplodin showed growth inhibitory effects against D. ciliaris. Three new β -resorcylic acid derivatives, 1 – 3 , were obtained from the endophytic strain Lasiodiplodia theobromae GI-1005, which was isolated from the mangrove plant Rhizopora mucronata. The structures of new compounds together with five known compounds were elucidated by NMR and MS analyses, and chemical means. The isolated compounds were evaluated for phytotoxicity against Digitaria ciliaris (southern crabgrass) and Lactuca sativa (lettuce). Compound 1 showed growth inhibitory effects against D. ciliaris in a dose-dependent manner.
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