Abstract
In herbalism, botanical supplements are commonly believed to be safe remedies, however, botanical supplements and dietary ingredients interact with transport and metabolic processes, affecting drug disposition. Although a large number of studies have described that botanical supplements interfere with drug metabolism, the mode of their interaction with drug transport processes is not well described. Such interactions may result in serious undesired effects and changed drug efficacy, therefore, some studies on interaction between botanical supplement ingredients and drug transporters such as P-gp and OATPs are described here, suggesting that the interaction between botanical supplements and the drug transporters is clinically significant.
Highlights
Health improvement and the treatment or prevention of diseases through the use of botanical supplements has been increasingly adopted over recent decades [1]
The pharmacokinetics and pharmacodynamics of drugs coadministered with botanical supplements are significantly altered
This review article discusses the effects of some botanical supplements on drug transporters in the intestinal and hepatic cells, since the bioavailability of orally administered drugs depends on the first pass effect
Summary
Health improvement and the treatment or prevention of diseases through the use of botanical supplements has been increasingly adopted over recent decades [1]. This trend may be attributed to the general concept that botanicals are nontoxic because of their natural source and an extensive traditional usage history [2]. On concomitant administration with drugs, botanical supplements may modulate drug metabolism or/and interact with transporters, resulting in their interaction with drugs [4] This may subsequently influence the pharmacokinetic and pharmacodynamic properties of drugs, leading to their changed efficacy and undesired effects [5,6]. Molecules 2017, 22, 1699 of studies on in vitro mechanistic and clinical evaluation of numerous botanicals is available in literature, limited studies are described here
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