Abstract
BackgroundThe spices, cinnamon and turmeric have both culinary and pharmaceutical applications. Earlier studies proved their effect on reducing the symptoms associated with type 2 diabetes, a major lifestyle disease affecting millions world over. In our work, we prepared a bi-herbal extract of cinnamon and turmeric and studied its effect to alleviate the symptoms of type 2 diabetes in rat model.MethodThe phenolic rich bi-herbal extract was given to diabetes induced male wistar rats for 28 days at two different concentrations (50 and 150 mg/Kg bwt.). The changes in blood glucose level were monitored at weekly interval. At the end of the experiment, blood serum was collected and used for the estimation of lipid profile, Glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), Total Protein (TP), Albumin, Urea and Creatinine levels.ResultThe serum analysis revealed that administration of the bi-herbal extract at 150 mg/Kg bwt. significantly reduced the blood glucose level (152.60 ± 40.2 mg/dL; p < 0.05) of diabetic animals as compared to diabetic control (335.40 ± 67.3 mg/dL; p < 0.05) at the end of 4 weeks. The treatment also resulted in the reduction of total cholesterol and LDL-cholestrol levels as compared to diabetic control animals. The histopathological examination of tissues showed the improvement in pancreatic architecture and restoration of tissue integrity in liver and kidney.ConclusionThe study concludes that methanol extract of combination of cinnamon and turmeric has good hypoglycemic, hypolipidemic and organ protective potential in diabetic rats which could be developed into functional food supplementation for the prevention of type 2 diabetes.
Highlights
The spices, cinnamon and turmeric have both culinary and pharmaceutical applications
The study concludes that methanol extract of combination of cinnamon and turmeric has good hypoglycemic, hypolipidemic and organ protective potential in diabetic rats which could be developed into functional food supplementation for the prevention of type 2 diabetes
Plant collection and preparation Turmeric variety, IISR Prathibha with high curcumin content (~ 5%) released from Indian Council of Agricultural Research (ICAR) - IISR and dried bark of true cinnamon, Cinnamomum zeylenicum collected from Alakkode (Kannur) estate of Plantation Corporation of Kerala Limited were used in the study
Summary
The spices, cinnamon and turmeric have both culinary and pharmaceutical applications. Earlier studies proved their effect on reducing the symptoms associated with type 2 diabetes, a major lifestyle disease affecting millions world over. We prepared a bi-herbal extract of cinnamon and turmeric and studied its effect to alleviate the symptoms of type 2 diabetes in rat model. Non-Insulin Dependent Diabetes Mellitus (NIDDM) popularly known as Type-2 diabetes is a biochemical metabolic disorder wherein the ability of cells to utilize blood glucose is reduced leads to metabolic abnormalities [1]. People with Insulin-Dependent Diabetes Mellitus (IDDM), otherwise known as Type-1 diabetes have to rely on. Few clinical studies in humans proved its effect against type 2 diabetes [9, 10]. Cinnamon contains numerous bioactive compounds of phenolics and flavonoids category which individually or synergistically found to have antidiabetic properties [8]
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