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Abstract
Phytosynthesis particles are the efficient activity of biomedical and environmental. In this present study, the green synthesis of titanium dioxide (TiO2) nanoparticles using the king of bitter herbal plant Andrographis paniculata was synthesized and characterized using XRD, SEM, HRTEM, AFM, and antimicrobial, antioxidant, and antidiabetic activities. The size of the particles HRTEM shows 50 nm, and SEM shows the spherical shape, which reveals the synthesis of TiO2 nanoparticles. XRD spectrum shows crystallinity of nanoparticles, and an average size is calculated about 22.97 nm. The phytosynthesis TiO2 shows the antioxidant and antidiabetic activities. Similarly, toxicity studies have demonstrated the hatching and viability LD 50 value of TiO2 250 μg/L. The current study's findings suggested that phytosynthesis TiO2 using extract of Andrographis paniculata exposure to potential hazard factors to biomedical and environmental uses.
Highlights
Nanotechnology appears as a rapidly growing field of science and technology for manufacturing new materials at the nanoscale level
UV-Vis Spectra Analysis. e optical properties of the synthesized TiO2 nanoparticle were studied using UV-Vis spectroscopic analysis, which mainly depends on surface plasmon resonance (SPR), which is used to measure the material adsorption onto the surface of metal nanoparticles [13, 33]
Titanium dioxide nanoparticles were green synthesized using Sesbania grandiflora leaf extract, and the results showed a higher malformation rate in 48–72 hpf zebrafish embryos at the highest concentration of 2.5 mg/L [50]. e current study results proved that Andrographis paniculata leaf extract-mediated titanium dioxide nanoparticles at the lowest concentration (250 μg/L) does not cause any malformation in zebrafish embryos
Summary
Nanotechnology appears as a rapidly growing field of science and technology for manufacturing new materials at the nanoscale level. Nanotechnology has a wide application in various fields such as biology, chemistry, physics, and medicine [1]. Nanomaterials are classified into organic and inorganic materials. Metal and metal oxide nanoparticles have great attention in physical, chemical, biological, medical, optical, mechanical, and engineering sciences. Novel techniques are introduced to examine and manipulate single atoms and molecules [2, 3]. Various physical and chemical methods synthesized metal oxide nanoparticles. Some commonly used methods are nonsputtering, solvothermal, reduction, sol-gel technique, and electrochemical technique. Ese methods are costly, toxic, highpressure, high-energy, and potentially hazardous [4,5,6,7] Some commonly used methods are nonsputtering, solvothermal, reduction, sol-gel technique, and electrochemical technique. ese methods are costly, toxic, highpressure, high-energy, and potentially hazardous [4,5,6,7]
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