Phytopharmacological Assessment from Two Medicinal Plants Used for Analgesic and Anti-inflammatory Purposes in Burkina Faso

Abstract

The purpose of this investigation was to elucidate the anti-nociceptive and anti-inflammatory properties of aqueous acetone extracts from <em>Cienfuegosia digitata</em> Cav; and <em>Sida Alba</em> L. in Swiss mice, with an aim to provide a scientific basis for the traditional use of these plants in the treatment of inflammation disorders. In anti-inflammatory activity, the carrageenan-induced paw edema and oil croton-induced ear edema in Swiss mice. As for analgesic effects, acetic acid writhing and formalin test methods were used in mice. About anti-inflammatory potential, the extracts at doses of 100; 200 and 400 mg/kg body weight produced significant comparatively to the control groups (p<0.05; p<0.01 and p<0.001) and we noticed a dose-dependent anti-inflammatory activity. The dose-dependent inhibition of edema was observed at 1; 2 and 3 h. However, extracts showed dose-dependent inhibition of croton oil induced ear oedema, at doses of 200; 300 and 500 &mug/ear. As for analgesic activity, extracts produced significant analgesic effects in acetic acid writhing and formalin test method (p<0.05; p<0.01 and p<0.001) compared to the control groups and a dose-dependent inhibition was observed. The present study concludes that <em>Cienfuegosia digitata</em> Cav. and <em>Sida Alba</em> L. have anti-inflammatory and analgesic properties.