Abstract
The global use of secondary metabolites like flavonoids, plant sterols, and alkaloids has been increasing due to their therapeutic benefits and fewer side effects compared to modern medicines. However, despite promising in vitro results, many herbal drugs and extracts demonstrate limited effectiveness in vivo due to their low lipid solubility and poor bioavailability. To address this issue, novel formulation strategies, particularly lipid-based delivery systems, are being proposed as carriers to enhance their bioavailability. This study focuses on the pharmaceutical development of liposomes that encapsulate three phytoconstituents, namely quercetin, berberine, and phytosterol, using the Quality by Design (QbD) concept. The Ishikawa diagram was utilized to identify the key factors affecting formulation quality, and the statistical experiment design concept was employed to optimize these factors. The liposomes were designed using the screening with the Placket-Burman approach and further optimized using the Box-Behnken method. The optimized liposomes exhibited an ideal size and achieved high entrapment efficiencies of 80.6%, 81.3%, and 80.35% for quercetin, berberine, and phytosterol, respectively. These liposomes were prepared using Phospholipon 90 G and cholesterol through the thin film hydration method. The resulting liposomes were thoroughly characterized and evaluated for morphology, % drug release, pharmacodynamic investigation, and stability studies.
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