Phytoconstituents based nanomedicines for the management of psoriasis

Abstract

Psoriasis is an autoimmune disease of skin which is also inflammatory and proliferative in nature. Psoriasis is mediated by T-cell activation and identified by distinct, drab-red or peach-pink stiffen patches with silvery scales causing characteristic lesion on skin. It also results in epidermal proliferation, aberrant keratinization, hyperkeratosis, dilated micro-vessels, and inflammatory cell infiltration. Conventional pharmacotherapies present can only give benefits up to a limited extent. Nanotechnology based nanomedicines provide a great opportunity for the improvement in the efficacy and safety of pharmaco therapeutic agents for psoriasis. In this review we discuss the Phytochemicals that is natural compounds present in plants extensively used for the antipsoriatic activity. Phytochemicals target cytokines signalling pathways and thus exhibiting their antipsoriatic activity. We further outline the advantages of loading phytoconstituents as drug in nanocarriers such as liposomes, niosomes, transferosomes and proniosomes for better and enhanced topical treatment. This review is mainly focused on usage of herbal nanomedicines in psoriasis, nano delivery carriers used in the delivery of phytoconstituents with an enhanced therapeutic profile and less toxicity. The intention of the study is to review herbal nanomedicines with better efficacy for the management of psoriasis. In recent years the phytoconstituents that are showing there antipsoriatic potential and Phytoconstituents loaded based nanomedicines have high treatment potential in the management of psoriasis.