Phytochemicals used as inhibitors in the treatment of ovarian cancer: A Mini-review

Abstract

Cancer occurs when cells begin to grow abnormally and abruptly in the body. Cancer is one of the dangerous diseases due to which many people die in the world. Many kinds of cancers occur in the human body in which ovarian cancer is also one of the most fatal cancers found among women. It causes many deaths in women. Ovarian cancer generally occurs because of hereditary. Both types of molecules can be used in medicines; i.e., synthesized by man in the laboratories and naturally occurring molecules. Phytochemicals are the naturally occurring molecules found in plants. Phytochemicals are of great importance nowadays because our research is more focusing on plant-based molecules which can be helpful in the treatment of any kind of disease and have fewer side effects. In this review article, we examined how various phytochemicals are utilized as inhibitors in the therapy of ovarian malignancy. Phytochemicals including flavonoids, terpenes, and organo-Sulphur compounds have antioxidant, anti-inflammatory, antitumor, antiviral, apoptosis induction, anti-proliferation, and cell cycle arrest induction properties that help in the inhibition of CAOV3, OVCAR3, OVCAR5, TOV112D, and A2780 ovarian cancer cells. Also helps in suppressing the expression of c-Myc (cellular-Myc: An oncogene on chromosome 8q24 of cellular), VEGF (Vascular endothelial growth factor), and NF-κB (Nuclear factor-kappa B) in ovarian cancer cell lines.