Abstract
The phytochemicals in the leaves of Cotoneaster mongolica Pojark, as well as their antioxidant and acetylcholinesterase (AChE) inhibitory activity were studied. The methanol extract of the leaves showed acetylcholinesterase inhibitory activity (IC50, 32.61 ± 0.51 μg/mL). The n-butanol fraction of this extract exhibited DPPH radical scavenging (IC50, 55.70 ± 0.15 μg/mL) and AChE inhibitory activity (IC50, 72.50 ± 0.60 μg/mL). From the n-butanol fraction quercetin (1), hyperoside (2), kaempferol-5-O-β-D-glucopyranoside (3), sissotrin (4), ursolic acid (5), corosolic acid (6), euscaphic acid (7), prunasin (8), (2R)-mandeloyl-β-D-glucopyranose (9), (Z)-3-hexenyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (10), benzyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (11) and arbutin (12) have been isolated and identified. Hyperoside, one of the major constituents among the isolated compounds, was active in both tested assays. Flavonol derivatives could provide the activity of this plant species.
Highlights
In the Mongolian flora, the genus Cotoneaster (Rosaceae) contains 4 represented species: C.mongolica
Shoots, twigs and leaves of Cotoneaster species as crude drugs are mainly used in the form of infusion, extract, tincture, tea and juice in traditional Mongolian medicine for the cure of intestinal inflammatory diseases, diarrhea, stomach indigestion, bowel disorders and abdominal cavity ascites, as well as rheumatoid arthritis
Cotoneaster species occurring in Russia, Iran, Uzbekistan, Turkey and Caucasia are used in traditional medicine, especially for the treatment of neurasthenia, nervous prostration, nasal hemorrhage, excessive menstruation, neonatal jaundice and cough [4,5,6]
Summary
In the Mongolian flora, the genus Cotoneaster (Rosaceae) contains 4 represented species: C.mongolica. No data were found on the biological activity of this plant species.In this study, phytochemicals in the leaves of C.mongolica, their antioxidant and acetylcholinesterase inhibitory activity were investigated. The absorbance was measured at 517 nm and the anti-oxidative activity (AA) was expressed in percentage: АA%=100- { [ (Abssample- Absblank) ×100] / Abscontrol}; Methanol (1.5 mL) added to the plant extract solution (1.5 mL) was used as a blank.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
