Abstract
Gynecological cancer confers an enormous burden among women worldwide. Accumulating evidence points to the role of phytochemicals in preventing cervical, endometrial, and ovarian cancer. Experimental studies emphasize the chemopreventive and therapeutic potential of plant-derived substances by inhibiting the early stages of carcinogenesis or improving the efficacy of traditional chemotherapeutic agents. Moreover, a number of epidemiological studies have investigated associations between a plant-based diet and cancer risk. This literature review summarizes the current knowledge on the phytochemicals with proven antitumor activity, emphasizing their effectiveness and mechanism of action in gynecological cancer.
Highlights
There is a dynamic increase in the number of cancer cases around the world.A total of 18.1 million new cases were reported in 2018, of which nearly 10 million were fatal [1]
human papilloma virus (HPV) testing is an important part of gynecological cancer screening, and immunization against HPV using vaccines has been a major step forward towards gynecological cancer prevention [8]
Due to the experimentally proven anticancerogenic effects of the selected phytochemicals, research is currently underway to assess their possible use in cancer prevention—including gynecological cancers
Summary
There is a dynamic increase in the number of cancer cases around the world. High-risk human papillomaviruses (HR-HPVs) are considered as the main etiologic factors of female lower genital tract malignancies [7] For this reason, HPV testing is an important part of gynecological cancer screening, and immunization against HPV using vaccines has been a major step forward towards gynecological cancer prevention [8]. There has been an increasing number of studies indicating the possible anticancer effects of individual dietary components, especially those of plant origin [5]. For this reason, the authors present the results of epidemiological, experimental, and clinical studies indicating the possibility of using a plant-based diet and its components in the prevention of gynecological cancer. The fundamental goal of this review was to discuss the clinical significance and possible benefits of phytochemicals in the chemoprevention of female reproductive system cancers
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
