Abstract
Aims: Tinospora cordifolia is a herb used in the traditional folk medicine due to their health benefits. Studies reported the biochemical composition and some biological properties of the plant stem. The aim of the current study was to investigate the antimicrobial and cytotoxic properties from the extract of Tinospora cordifolia stem.
 Place and Duration of Study: The study was accomplished by eleven months in the Department of Pharmacy, University of Science and Technology Chittagong (USTC), Bangladesh. 
 Methodology: Presence of phytochemical constituents such as alkaloids, flavonoids and tannins, saponins were evaluated. Antimicrobial activity of the stem extract was assayed separately using an agar diffusion method against some gram negative and gram positive bacteria. The cytotoxic potential of the stem extract was evaluated by the Brine-Shrimp Lethality Assay mathod. 
 Results: The zone of inhibition formed by the methanolic extract in the antimicrobial assays was significant. In addition, cytotoxicity of the extract was found to be significant as compared to the standard gallic acid in Brine-Shrimp lethality assay.
 Conclusion: The methanolic extract of Tinospora cordifolia may possess significant antimicrobial property which requires more studies to isolate the specific bioactive compound for developing a new antimicrobial agent from this plant.
Highlights
Nature has been a source of medicinal principles for many years and an impressive number of modern drugs have been isolated from natural sources
It has been reported that ethanolic extracts of Tinospora cordifolia show antimicrobial activity towards clinical isolates of methicillin-resistant and carbapenemase-producing bacteria [12]
The intensity of the component content were high in alkaloids, resin and antharaquinone glycosides, moderately present in steroids, terpenoids and others present in lower amounts (Table 1)
Summary
Nature has been a source of medicinal principles for many years and an impressive number of modern drugs have been isolated from natural sources. The herb Tinospora cordifolia (T. cordifolia) belongs to the Menispermaceae family and is commonly known as Gu-lancha or Tinospora in English and Giloya or Ambervel in Hindi It has a long history of use in Ayurvedic medicine (the traditional medicine of India). The extract of its stem stimulates bile secretion, causes constipation, enriches the blood and cures jaundice [14]. It is useful in skin diseases [15]. The aim of the present work was to evaluate the phytochemicals, cytotoxic and antimicrobial activities of T. cordifolia to assess the scientific basis of the traditional uses of these plants
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
