Abstract
<p>Phytotherapy is a discipline which is interested in the design, the preparation and the interpretation of structure activity relationship of the natural bioactive molecules. In this context, ethanolic leaves extract of <em>Melia azedarach</em> L. was phytochemically analysed on the bases of HPLC and by GC–MS. Extract wase tested for his in vitro antioxidant activities by 1,1-diphenyl-2-picrylhydrazyl (DPPH), H<sub>2</sub>O<sub>2</sub>, hydroxyl radical scavenging activity, Ferric Reducing Power (FRP) and Ferrous ion chelating abilities methods. The antioxidant activity of the extract was analyzed simultaneously with their pro-oxidant capacity. The ratio of pro-oxidant to the antioxidant activity (ProAntidex) represents a useful index of the net free radical scavenging potential of the synthesized compounds. Tested extract showed significant antioxidant activity with a moderate ProAntidex.</p><p><strong>Video clips:</strong></p><p><a href="https://youtube.com/v/FkqJ-qAoyNI">Ferrous ion chelating ability (FIC) 1</a></p><p><a href="https://youtube.com/v/LiZIYq54-ms">Ferrous ion chelating ability (FIC) 2</a></p><p><a href="https://youtube.com/v/dTNWTEQf8Hs">Ferrous ion chelating ability (FIC) 3</a></p><p> </p>
Highlights
Nowadays, an increasing demand to evaluate the antioxidant properties of plant extracts (McClements and Decker, 2000) have been observed for their safe use for scientific research as well as for industrial purposes excluding many synthetic anti-oxidants which have possible activity as promoters of carcinogenesis
Data demonstrate that M. azedarach leaves ethanolic extract contain 93.40 mg GA/ g DW of total phenols
We focus on phytochemically, phenolics profile and fatty acids composition of ethanolic leaves M. azedarach extract naturalised in Tunisia and its probable correlations with their antioxidant activity
Summary
An increasing demand to evaluate the antioxidant properties of plant extracts (McClements and Decker, 2000) have been observed for their safe use for scientific research as well as for industrial purposes excluding many synthetic anti-oxidants which have possible activity as promoters of carcinogenesis. Among the numerous families with recognized botanical pharmacological activities, those belonging to Meliaceae family deserve mention. Native to India and China, it is found in Africa, Australia, America and Arab countries (Khan et al, 2011). This tree is widespread in Tunisia as an ornamental shade tree characterized by abundant foliage and it will be interesting if it will successfully managed
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