Abstract
Medicinal plants have been used since ancient times for their various therapeutic activities and are safer compared to modern medicines, especially when properly identifying and preparing them and choosing an adequate dose administration. The phytochemical compounds present in plants are progressively yielding evidence in modern drug delivery systems by treating various diseases like cancers, coronary heart disease, diabetes, high blood pressure, inflammation, microbial, viral and parasitic infections, psychotic diseases, spasmodic conditions, ulcers, etc. The phytochemical requires a rational approach to deliver the compounds to enhance the efficacy and to improve patients’ compatibility. Nanotechnology is emerging as one of the most promising strategies in disease control. Nano-formulations could target certain parts of the body and control drug release. Different studies report that phytochemical-loaded nano-formulations have been tested successfully both in vitro and in vivo for healing of skin wounds. The use of nano systems as drug carriers may reduce the toxicity and enhance the bioavailability of the incorporated drug. In this review, we focus on various nano-phytomedicines that have been used in treating skin burn wounds, and how both nanotechnology and phytochemicals are effective for treating skin burns.
Highlights
Skin is the largest visible and vulnerable organ of the human body
The nanofibers of emodin in polyvinylpyrrolidone were harmless, anti-allergenic, rated into cellulose acetate caused an improvement in fibroblast proliferation, enhanced bioactive, and dissolved at a rapid rate when compared to the pure compound
The freshly developed nanocrystal bacterial cellulose hydrogels instantly stick to fibroblasts, support human dermal fibroblast morphology, restrict the relocation of cells, enhance the proliferation of cells, and influence the nine expressions of genes connected to healing of injury
Summary
Skin is the largest visible and vulnerable organ of the human body. It protects our body from environmental changes and dehydration [1,2]. There are certain skin conditions, such as burns and other substantial loss of the outer layer of the skin (epidermis), which acts as the barricade that prevents the skin from degeneration and microbial incursion and balances the fluid levels of the body. In such conditions, both nutritional and electrolytes constituents get demolished. Healing of burn wounds is a complicated process, and it proceeds through various phases, including inflammation, proliferation, and remodeling. Novel drug delivery systems help achieve the required therapeutic effects with reduced adverse events and enhance the bioavailability of herbal constituents [19,20]. We focused mainly on the last 15 years of works in this area, some older references were included to provide validity to the review
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