Abstract
Rhodiola rosea L. is a plant species with highly recognized adaptogenic properties and hence with an intensive application in traditional medicine, as well as, in clinical practice. The plant is characterized by a high phytochemical variability, depending on the geographical location among others. In this study, we report on the application of NMR-based metabolomics (1D and 2D) combined with multivariate data analysis and an HPLC method development for quantitative determination of the metabolic differences in R. rosea rhizomes, roots and aerial parts from its natural habitat in Bulgaria.In the rhizomes the content of salidroside, rosarin, rosavin and rosin was 2.67%, 0.37%, 1.97% and 0.04%, respectively, while their respective amounts in the roots were 0.31%, 0.06%, 0.39% and 0.01%.
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