Abstract
The plant Krameria pauciflora MOC et. Sessé ex DC. is used as an anti-inflammatory and antidiabetic in traditional medicine. The aim of this study was to evaluate the in vivo anti-inflammatory and antidiabetic effects of a methanol extract from the roots of K. pauciflora. Dichloromethane and ethyl acetate extracts obtained by partitioning the methanol extract were also evaluated. Complete methanol and dichloromethane extracts showed anti-inflammatory effects at 3 mg/kg. An anti-inflammatory effect similar to indomethacin (10 mg/kg) was observed when the methanol and dichloromethane extracts, which contain a cycloartane-type triterpene and an sterol, were administered orally at several doses (3, 10, 30 and 100 mg/kg), whereas no anti-inflammatory effect was observed at any dose for the ethyl acetate extract, which contains catechin-type flavonoids. The antidiabetic effect of each extract was also determined. An antihyperglycaemic effect was observed in diabetic rats, but no effect in normoglycaemic animals was observed when the methanol extract was administrated at 30 mg/kg. All of the extracts exhibited radical scavenger activity. Additionally, constituents from all of the extracts were identified by NMR. This article supports the use of K. pauciflora as an anti-inflammatory because it exhibits a similar effect to indomethacin. However, its antidiabetic effect is not completely clear, although it could be useful for preventing diabetic complications.
Highlights
Non-steroidal anti-inflammatory drugs are one of the best-selling groups of drugs globally.Inflammation is a part of the immune response against infection and has been implicated in a broad range of diseases, including diabetes, cancer, hypertension and atherosclerosis [1,2,3,4]
Because there are no reports of in vivo anti-inflammatory or antidiabetic effects for this species, we evaluated the in vivo effect of the roots of K. pauciflora on both disorders and its in vitro antiradical activity as well as identified its main constituents
Krameria pauciflora, used as an anti-inflammatory and antidiabetic remedy was the object of the present study
Summary
Non-steroidal anti-inflammatory drugs are one of the best-selling groups of drugs globally. Inflammation is a part of the immune response against infection and has been implicated in a broad range of diseases, including diabetes, cancer, hypertension and atherosclerosis [1,2,3,4]. Throughout history, people have used medicinal plants to treat diseases and illness such as diabetes. 13,500 reports on the anti-inflammatory effects of plant extracts and more than 4,200 articles about the antidiabetic effects of vegetal extracts. It is interesting to note that some antidiabetic species exhibited an anti-inflammatory effect and vice versa [6,7]. The roots of the Krameria species are used in traditional medicine as a remedy for inflammation, diarrhoea, infection and cancer as well as for its photoprotective activity
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