Abstract
Anti-inflammatory activity of fractionated extracts of Salvia officinalisValeria Dal Pra, Lais B. Bisol, Suelen Detoni, Marjorie Denti, Jaine Grando, Camila Pollo, Tiago R. Pasquali, Arno Ernesto Hoffmann, Marcio A. Mazutti, Sandra M. D. Macedo
Highlights
Psychotria L. is the largest genus in the tribe Psychotrieae (Rubiaceae) and is comprised of around 2000 species worldwide, distributed in tropical regions (Nepokroeff et al, 1999).Many biological and pharmacological investigations of the genus Psychotria have shown a significant number of activities, such as antioxidant (Formagio et al, 2014), antibacterial (Moraes et al, 2011), anti-parasitic (Kato et al, 2012), antitumor (Gerlach et al, 2010), anti-inflammatory (Iniyavan et al, 2012), anxiolytic and anti-depressive (Farias et al, 2012), and anti-epileptic (Awad et al, 2009) activities
An in vivo anti-inflammatory assay was conducted on Psychotria stenocalyx ethanol extract of leaves, evaluating this effect on cell migration and exudate formation in a murine carrageenan-induced model of pleurisy
The acid extract was alkalinized with 10% NH4OH in water up to pH 11 and extracted again with ethyl acetate yielding the purified alkaloid fraction (3.24 g/100g CE) which was used for the isolation and characterization of alkaloids
Summary
Psychotria L. is the largest genus in the tribe Psychotrieae (Rubiaceae) and is comprised of around 2000 species worldwide, distributed in tropical regions (Nepokroeff et al, 1999).Many biological and pharmacological investigations of the genus Psychotria have shown a significant number of activities, such as antioxidant (Formagio et al, 2014), antibacterial (Moraes et al, 2011), anti-parasitic (Kato et al, 2012), antitumor (Gerlach et al, 2010), anti-inflammatory (Iniyavan et al, 2012), anxiolytic and anti-depressive (Farias et al, 2012), and anti-epileptic (Awad et al, 2009) activities. Psychotria L. is the largest genus in the tribe Psychotrieae (Rubiaceae) and is comprised of around 2000 species worldwide, distributed in tropical regions (Nepokroeff et al, 1999). Arg. is a shrub that grows up to two meters, and occurs in coastal tropical forests of South and Southeast Brazil, ranging from Rio de Janeiro to Santa Catarina (Taylor et al, 2015). It is popularly known as “gandiúva-d’anta” and “café-d’anta” (Dillenburg et al, 1985)
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