Abstract
The present investigation deal to phytochemical studies of Theriophonum minutum (TM) extracts and evaluation of its anticancer potential. The dried plant of TM was successively extracted with petroleum ether, ethyl acetate, ethanol, hydro-alcoholic and water. Various extracts of TM reveal the presence of sterols, flavonoids, alkaloids, glycoside, etc. TM extracts elicited significant in vitro antimitotic and antiproliferative assay by Allium cepa root inhibition and yeast proliferation model respectively. Ethyl acetate TM extract (200 mg/mL) exhibited interruption in cell proliferation of yeast as observed by marked reduction in number of dividing cells and inhibition of cell viability compared to control. Ethanolic extract of TM (100 mg/mL) has demonstrated significant inhibitory root growth in Allium cepa model. Therefore it was further evaluated by sulforhodamine B (SRB) assay in cell culture of human prostate (PC3), colon cancer (Colo-205) cell lines. Despite of significant antimitotic and antiproliferative activity, ethanolic TM extract exhibited low cytotoxicity in SRB assay.
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