Abstract
Xao tam phan (Paramignya trimera (Oliv.) Guillaum) is a traditional herbal medicine in Vietnam. Previous investigations reported mainly compounds and bioactivities of roots, stems, and leaves while there is limited information about those of fruits. This study aims to reveal the difference in the chemical profile of defatted peel (DP) and nondefatted peel (NDP) methanolic extracts of P. trimera using colorimetric reactions and liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) analysis. We also showed the potential antibacterial activity of two extracts against clinically isolated bacteria strains including P. aeruginosa, Salmonella sp., and S. aureus with the MIC values < 100 μg/mL. This preliminary result proves the traditional usage of this herbal medicine and can be helpful for further investigation on the isolation and identification of the new compounds in P. trimera peels.
Highlights
Paramignya trimera (Oliv.) Guillaum, locally named “Xao tam phan,” belongs to the Paramignya genus of the Rutaceae family, mainly in the south of Vietnam [8]. is native plant is a traditional remedy used for liver protection and infectious disease treatment
The research on the bioactivity and chemical composition of P. trimera fruits has been limited. is study aims to phytochemically dereplicate the defatted peel (DP) and nondefatted peel (NDP) methanolic extracts of P. trimera and to determine the activity against multidrug-resistant bacterial strains clinically isolated from patients in Vietnam
Two extracts were rich in flavonoids and glycosides. ese tests showed relatively that alkaloids, flavonoids, and glycosides were found with higher concentrations in DP than NDP
Summary
Paramignya trimera (Oliv.) Guillaum, locally named “Xao tam phan,” belongs to the Paramignya genus of the Rutaceae family, mainly in the south of Vietnam [8]. is native plant is a traditional remedy used for liver protection and infectious disease treatment. Various potential bioactivities, i.e., antioxidant, antibacterial, and anticancer activities and hepatoprotective property, were reported from the plant’s roots, leaves, and stems. Many compounds that belong to coumarins, acridone alkaloids, phenols, flavonoids, and chromenes classes have been isolated from these tissues (Table 1S, Supplementary Materials) [9,10,11,12,13,14,15,16,17,18,19]. Being a perennial woody plant, the exploitation of this plant from other tissues, i.e., fruits, instead of roots, leaves, or stems, may provide a chance to conserve this valuable medicinal plant. Is study aims to phytochemically dereplicate the defatted peel (DP) and nondefatted peel (NDP) methanolic extracts of P. trimera and to determine the activity against multidrug-resistant bacterial strains clinically isolated from patients in Vietnam The research on the bioactivity and chemical composition of P. trimera fruits has been limited. is study aims to phytochemically dereplicate the defatted peel (DP) and nondefatted peel (NDP) methanolic extracts of P. trimera and to determine the activity against multidrug-resistant bacterial strains clinically isolated from patients in Vietnam
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