Abstract
Effect of Aframomum melegueta on carbon tetrachloride induced liver injuryIdoh Kokou, Karou S. Damintoti, Agbonon Amegnona, Adjrah Yao, Gbeassor Messanvi
Highlights
Cancer accounts for the second leading cause of global deaths after cardiovascular disease, especially in developed countries
This study is aimed at the identification of potential antiprostate phytochemicals in ethanolic extract of Aframomum melegueta, acting through a “one-drug-multipletarget” approach using a network of computational tools
Since the pathogenesis of prostate carcinoma includes the damaging of the prostate epithelium which could be triggered by procarcinogenic inflammatory processes, the progression of which may result in the generation of proliferative inflammatory atrophy lesions
Summary
Cancer accounts for the second leading cause of global deaths after cardiovascular disease, especially in developed countries. Since the pathogenesis of prostate carcinoma includes the damaging of the prostate epithelium which could be triggered by procarcinogenic inflammatory processes, the progression of which may result in the generation of proliferative inflammatory atrophy lesions. Through these important pathomechanisms, the pharmacological responses usually observed include the prevention of cell injury, clearance of necrotic cells, initiation of tissue repair, and other inflammatory processes (Fouzia and Salim, 2019). Bioactive agents with anti-inflammatory and antioxidant potentials with the expression for androgen modification such as spironolactone, progestogen, and flutamide are among the common markers against the development of carcinomas including prostate (Bardia et al, 2009)
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