Abstract
Article history: With an objective of developing some novel analgesic and antiinflammatory natural agents with fast acting and low toxicity profile here in, the different extracts of Phaseolus vulgaris (Linn) seeds were evaluated for analgesic and antiinflammatory activities using glacial acetic acid induced writhing and carrageenan induced rat paw oedema method respectively. For screening of the extracts for analgesic and antiinflammatory activities aspirin and diclofenac were used as standard drugs respectively. Petroleum ether extract exhibited significant analgesic and antiinflammatory activities. The petroleum ether extract can be considered as a potential candidate for analgesic and antiinflammatory activities. The presence of steroids and flavonoids in petroleum ether extract of Phaseolus vulgaris Linn., seeds could be attributed for the analgesic and antiinflammatory activities.
Highlights
Inflammation is a body’s defense mechanism in response to various infectious or metabolic stimuli
This is because NSAID’s exhibit antiinflammatory and analgesic activity and cause gastrointestinal complications ranging from dyspepsia to upper GI tract bleeding and perforation
The present study provides an evidence for the analgesic and antiinflammatory activities of Phaseolus vulgaris (Linn) seeds
Summary
Inflammation is a body’s defense mechanism in response to various infectious or metabolic stimuli. Suppression of inflammation still continues to be a challenge to the scientists despite the availability of number of NSAID’s. This is because NSAID’s exhibit antiinflammatory and analgesic activity and cause gastrointestinal complications ranging from dyspepsia to upper GI tract bleeding and perforation. Complete inhibition of COX-1 is not preferred and drugs that selectively inhibit COX-2 are better antiinflammatory agents. Another field of greater concern is synthesis of more effective analgesic agents. Phaseolus vulgaris (Linn) seeds belong to the family of Fabaceae (Romero-Arenas et al, 2013)
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