Abstract
<p>The aim of this study was to evaluate diuretic activity of aqueous methanolic extract of <em>Euphorbia granulate</em> in rats. Albino rats were divided into five groups. Group I served as reference, Group II as standard and Group III, IV and V served as test. The three doses of extract (30, 50 and 100 mg/kg) were given to rats (i.p) in acute diuretic model. Furosemide (10 mg/kg i.p) was used as standard drug. The extract induced diuretic effects and induced electrolytes excretion in a dose-dependent manner when compared with control. The extract (100 and 50 mg/kg) significantly (p&lt;0.01) increased the volume of urine in comparison to control group. Similarly, the excretion of potassium and sodium were also significantly (p&lt;0.05) increased following extract administration. However, there was no significant change in the pH of urine samples of the extract-treated group compared with control. The result of this study thus offers support to the traditional folker use of this plant as a diuretic agent.</p><p> </p>
Highlights
Diuretics are the drugs which are used to enhance urinary output and electrolyte excretion
Plant specimen was identified by Taxonomist, Cholistan Institute of Desert Studies (CIDS), The Islamia University of Bahawalpur, Pakistan and a specimen was deposited there in the herbarium with voucher number 3730/CIDS/IUB
The results showed that E. granulate aqueous methanol extract exhibited a significant but dose dependent diuretic effects when compared with the control
Summary
Diuretics are the drugs which are used to enhance urinary output and electrolyte excretion. They show their action mostly on different parts of nephrons and increases urine outflow. Diuretics can increase the electrolytes elimination (Bhavna and Rani, 2006). Its latex is used as a purgative, anthelmintic and diuretic, as well as for its blood purifying characteristics in Saudi Arabia (Schmelzer and Gurib-Fakim, 2008). It shows inhibitory effects against Human immunodeficiency virus (HIV-1) protease (Hussein et al, 1999).
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